Effector Activity Heart by Separable Effects on Migration and T-bet Controls Pathogenicity of CTLs in the
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بررسی فعالیت سلولهای کشنده طبیعی در بیماران سرطانی و مقایسه با افراد سالم
Among immune system components natural killer (NK) cells are the first line of defence against tumor cells. The decreasing activity of these cells can be associated with carcinogenesis, in situ tumor growth and metastasis of different cancers, viral infections, immunodeficiency syndroms and autoimmune diseases. In this study natural killer activity of peripheral blood mononuclear cells (Effecto...
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The complex relationship between Th1 and Th17 cells is incompletely understood. The transcription factor T-bet is best known as the master regulator of Th1 lineage commitment. However, attention is now focused on the repression of alternate T cell subsets mediated by T-bet, particularly the Th17 lineage. It has recently been suggested that pathogenic Th17 cells express T-bet and are dependent o...
متن کاملEffect of Soluble HLA Class I Molecule on NK/LAK Cells Activation Induced by Poly I:C
Background: Natural Killer cells express killer inhibitory receptors specific for HLA-class I molecules. These receptors could induce signals that determine NK cells ability to mediate cytotoxicity. Purified soluble form of HLA class I molecules (sHLA) could bind to NK cell receptors and down-regulate the NK killer function. Objective: To evaluate the influence of sHLA and two monoclonal an...
متن کاملMidline 1 controls polarization and migration of murine cytotoxic T cells
Midline 1 (MID1) is a microtubule-associated ubiquitin ligase that regulates protein phosphatase 2 A levels. Loss-of-function mutations in MID1 lead to the human X-linked Opitz G/BBB (OS) syndrome characterized by defective midline development during embryogenesis. We have recently shown that MID1 is strongly up-regulated in murine cytotoxic T lymphocytes (CTLs), and that it has a significant i...
متن کاملT-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells.
Valpha14i natural killer T (NKT)-cell function has been implicated in a number of disease conditions. The molecular events that drive Valpha14i NKT-cell development remain elusive. We recently showed that T-bet is required for the terminal maturation of these cells. Here we identify some of the genetic targets of T-bet during Valpha14i NKT-cell lineage development. Microarray gene-expression an...
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تاریخ انتشار 2006